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Asymmetric cis - Hydroxylation via Epoxidation-Carboxylation: A Formal Synthesis of (+)-Citreoviral

โœ Scribed by Barry M Trost; John K Lynch; Steven R Angle


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
220 KB
Volume
28
Category
Article
ISSN
0040-4039

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An efficient formal synthesis of balanol
โœ Michael H. Wu; Eric N. Jacobsen ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 184 KB

An efficient formal synthesis of balanol is described. The thirteen-step sequence features a highly enantioselective (92% ee) ring opening of 1,4-cyclohexadiane monoepoxide with TMSN~ catalyzed by the Cr-salen complex 3. A selective Beckmann rearrangement followed by amide reduction and nitrogen fun