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Asymmetric catalysis in intramolecular cyclopropanation

✍ Scribed by Koskinen, Ari M. P.; Hassila, Heikki


Book ID
127158412
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
261 KB
Volume
58
Category
Article
ISSN
0022-3263

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Optically active Co(II)-salen complexes (5 and 7) were found to catalyze highly enantioselective intramolecular cyclopropanation of 2-alkenyl a-diazoacetates in the presence of N-methylimidazole under high substrate concentration.

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## Abstract We have examined the catalytic asymmetric intramolecular cyclopropanation (IMCP) reactions of 5‐aryl‐1‐diazo‐1‐mesitylsulfonyl‐5‐hexen‐2‐ones, and found that the substituent of the 5‐aryl group dramatically changes the enantioselectivity. That is, no enantioselectivity was observed when