𝔖 Bobbio Scriptorium
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Asymmetric bioreductions: application to the synthesis of pharmaceuticals

✍ Scribed by Michel Chartrain; Randolph Greasham; Jeffrey Moore; Paul Reider; David Robinson; Barry Buckland


Book ID
114395564
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
281 KB
Volume
11
Category
Article
ISSN
1381-1177

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Asymmetric synthesis of ACE inhibitor-Be
✍ Ching-Yao Chang; Teng-Kuei Yang πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 207 KB

An enantioselective synthesis of the potent angiotensin converting enzyme (ACE) inhibitor (2S, 3%S)-2-(1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester hydrochloride, Benazepril HCl 4, has been achieved through an asymmetric reduction of 4-(2-nit