𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Asymmetric aza-Diels–Alder reactions of indole 2-carboxaldehydes

✍ Scribed by Jeffrey T Kuethe; Ian W Davies; Peter G Dormer; Robert A Reamer; David J Mathre; Paul J Reider

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
111 KB
Volume
43
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The aza-Diels-Alder reaction of substituted indole 2-carboxaldehydes with Danishefsky's diene has been investigated. The reaction proceeds with a high degree of diastereoselectivity providing highly functionalized 2-(2-piperidyl)indoles which are further elaborated into novel polycyclic heterocycles.

📜 SIMILAR VOLUMES

Intramolecular diels-alder reactions of
Intramolecular diels-alder reactions of indoles
✍ George A. Kraus; Jeff Raggon; P.J. Thomas; Dan Bougie 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 209 KB

The first examples of intramolecular Diels-Alder reactions on indoles indicate that this reaction may be employed for the direct preparation of highly functionalized dihydroindoles. The hybridization of the atoms in the tether plays a crucial role.