Asymmetric allylic amination catalyzed by chiral ferrocenylphosphine-palladium complexes

✍ Scribed by Tamio Hayashi; Kohei Kishi; Akihiro Yamamoto; Yoshihiko Ito

• Publisher: Elsevier Science
• Year: 1990
• Tongue: French
• Weight: 298 KB
• Volume: 31
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)88870-x

✦ Synopsis

A palladium complex bearing chiml (hydroxyalkyl)ferrocenylphosphine ligand was found to be a highly regio-and stereoselective catalyst for the asymmetric allylic amination of 2butenyl acetates with benzylamine, the nucleophilic attack of the amine taking place selectively on the more substituted end of the r-allylpalladium intermediate to give optically active 3-benzylamino-1-butene of up to 84% ee.