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Asymmetric Alkylation of Diphenylmethane Derivatives Using (-)-Sparteine.

โœ Scribed by James A. Wilkinson; Stephen B. Rossington; John Leonard; Nigel Hussein


Publisher
John Wiley and Sons
Year
2004
Weight
99 KB
Volume
35
Category
Article
ISSN
0931-7597

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Asymmetric Syntheses of Derivatives of ฮฒ-and ฮณ-Aryl and ฮฑ-Alkyl Amino Acids Using n-BuLi/(-)-Sparteine. -Alkylation of N-Boc and N-arylmethyl or N-cinnamyl p-anisidines with BuLi/(-)-sparteine allows the efficient synthesis of highly enantioenriched derivatives which can be transformed into a varie