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Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

✍ Scribed by Sándor B. Ötvös; István M. Mándity; Ferenc Fülöp

Book ID
118474439
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
810 KB
Volume
295
Category
Article
ISSN
0021-9517

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✍ Arjan Odedra; Peter H. Seeberger 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB

## Abstract **Continuous organocatalysis**: Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5–10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 °C with reaction