✦ LIBER ✦
5-(Pyrrolidin-2-yl)tetrazole-Catalyzed Aldol and Mannich Reactions: Acceleration and Lower Catalyst Loading in a Continuous-Flow Reactor
✍ Scribed by Arjan Odedra; Peter H. Seeberger
- Book ID
- 101562626
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 348 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Continuous organocatalysis: Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5–10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 °C with reaction times ranging from 10 to 30 min.magnified image