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Asymmetric addition reaction of organozinc reagents to nitrones using a catalytic amount of external chiral auxiliary

✍ Scribed by Yutaka Ukaji; Yuuichi Kenmoku; Katsuhiko Inomata


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
168 KB
Volume
7
Category
Article
ISSN
0957-4166

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Nucleophilic Addition of Nitrones to Ket
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A new organic reaction has been discovered in which nitrones react with carbonyl compounds in an aldoltype reaction to give functionalized beta-hydroxynitrones. The alpha-carbon atom of the nitrone undergoes a nucleophilic addition reaction to electron-deficient ketones, such as alpha-ketoesters, al