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Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A

โœ Scribed by Cheng, Mou-Nuo; Wang, Hao; Gong, Liu-Zhu


Book ID
120278615
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
782 KB
Volume
13
Category
Article
ISSN
1523-7060

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A facile 1,3-dipolar cycloaddition of az
โœ Shanmugavel Uma Maheswari; Kamaraj Balamurugan; Subbu Perumal; Perumal Yogeeswar ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 582 KB

A facile 1,3-dipolar cycloaddition of azomethine ylide generated in situ from the reaction of 1,3-thiazolane-4-carboxylic acid and isatin to 2-arylidene-1,3-indanediones furnished novel dispiro-oxindolylpyrrolothiazoles regio-and stereo-selectively in moderate to good yields (60-92%). In vitro antit