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Astrocytes: regulation of brain homeostasis via apolipoprotein E

โœ Scribed by Jillian R. Gee; Jeffrey N. Keller

Book ID
116306893
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
88 KB
Volume
37
Category
Article
ISSN
1357-2725

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## Abstract The association of the E4 allele of apolipoprotein E (apoE4) as a genetic risk factor for Alzheimer's disease (AD) has been well established. Although recent studies in neuronal cell lines and transgenic mice have shown that apoE4 promotes neurodegeneration, the mechanisms through which