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Associations of Kras and Hedgehog signaling pathways and their role in pancreatic cancer

✍ Scribed by Mohelnikova-Duchonova, Beatrice; Brynychova, Veronika; Ihnatova, Ivana; Oliverius, Martin; Hlavsa, Jan; Mazanec, Jan; Honsova, Eva; Kala, Zdenek; Soucek, Pavel

Book ID
127289834
Publisher
S. Karger AG
Year
2014
Tongue
English
Weight
53 KB
Volume
14
Category
Article
ISSN
1424-3903

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## Abstract Pancreatic cancer is an aggressive malignancy that exhibits a number of genetic and epigenetic alterations. Indian hedgehog (Ihh) and its 2 signaling receptors, patched (Ptc) and smoothened (Smo), are involved in pancreatic development and regulation of β‐cell function as well as in cer