## Abstract Pancreatic cancer is an aggressive malignancy that exhibits a number of genetic and epigenetic alterations. Indian hedgehog (Ihh) and its 2 signaling receptors, patched (Ptc) and smoothened (Smo), are involved in pancreatic development and regulation of Ξ²βcell function as well as in cer
Expression and regulation of hedgehog signaling pathway in pancreatic cancer
β Scribed by Yinmo Yang; Xiaodong Tian; Xuehai Xie; Yan Zhuang; Wenhan Wu; Weimin Wang
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 548 KB
- Volume
- 395
- Category
- Article
- ISSN
- 1435-2451
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The Hedgehog (Hh) signaling pathway plays an important role in human development. Abnormal activation of this pathway has been observed in several types of human cancers, such as the upper gastroβintestinal tract cancers. However, activation of the Hh pathway in colorectal cancers is co
## Abstract The EGF family of ligands and receptors plays an important role in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC) and contributes to its aggressiveness. A number of molecular approaches have been developed to block these pathways, and studies have already proven the clinica