Association Testing for Next-Generation Sequencing Data Using Score Statistics
โ Scribed by Line Skotte; Thorfinn Sand Korneliussen; Anders Albrechtsen
- Book ID
- 112095651
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 798 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Efficient score tests for a twoโlocus model for quantitative traits are proposed for general pedigrees. Two search strategies, simultaneous search and conditional search, are considered. These tests are attractive alternatives to the likelihood ratio test for their asymptotic equivalenc
## Abstract Based on the symmetry of transmitted/nontransmitted alleles from heterozygous parents under the null hypothesis of no association, the work proposed here establishes a general statistical framework for constructing association tests with data from nuclear families with multiple affected