Association study between the dopamine receptor D4 gene and obsessive-compulsive disorder
β Scribed by Beatriz Camarena; Cristina Loyzaga; Alejandro Aguilar; Karen Weissbecker; Humberto Nicolini
- Book ID
- 118436783
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 107 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0924-977X
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Controversial results possibly suggesting an association between Tourette's Syndrome (TS) and excess of homozygosity at a Msc I polymorphism in the Dopamine D3 receptor (DRD,) gene have recently been reported. Since a relationship between Obsessive-Compulsive Disorder (OCD) and Tourette's Syndrome (
The dopamine D4 receptor is of major interest in schizophrenia research due to its high affinity for the atypical neuroleptic clozapine and a high degree of variability in the receptor gene (DRD4). Although several genetic linkage analyses performed on schizophrenia multiplex families from different