reported the existence of an association between schizophrenia and homozygosity of a BUZZ polymorphism in the first exon of the dopamine D3 receptor (DRDS) gene. In response to this report, further studies were conducted; however, these studies yielded conflicting results. In the present study, we e
Association studies in schizophrenia using a dopamine D3 receptor gene polymorphism
β Scribed by V.L. Nimgaonkar; X.R. Zhang; J.G. Caldwell; R. Ganguli; A. Chakravarti
- Book ID
- 118857003
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 151 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0006-3223
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DNA fragments from a genomic library were used to establish the partial structure of the human dopamine D3 receptor gene (DRD3). Its coding sequence contains 6 exons and stretches over 40,000 base pairs. The complete DRD3 transcript and three shorter variants, in which the second andor third exon ar
Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. N