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Association study of schizophrenia with dopamine D3 receptor gene polymorphisms: Probable effects of family history of schizophrenia?

✍ Scribed by Nimgaonkar, V. L. ;Zhang, X. R. ;Caldwell, J. G. ;Ganguli, R. ;Chakravarti, A.

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 484 KB
Volume: 48
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320480408

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✦ Synopsis

Using a case-control design, a reported association of schizophrenia with homozygosity at the dopamine D3 receptor gene locus was investigated in a group of patients (n = 53), with schizophrenia (DSM-III-R), and psychiatrically normal controls (n = 61), matched for ethnicity and area of residence. No significant differences in the distribution of alleles o r genotypes between the two groups could be detected. However, among patients with a family history of schizophrenia, as compared to controls without such family history, an association with allele 1 at this locus was noted (Odds ratio 12.4, c.I.1.61,96.35).

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