## Abstract Polymorphisms in DNA repair genes may be associated with differences in the capacity to repair DNA damage and thereby influence an individual's susceptibility to smokingβrelated cancer. To test this hypothesis, we investigated the potential association of 7 __XPC__ polymorphisms (β449Gβ
Association of XPC polymorphisms with breast cancer risk
β Scribed by Feng Xu; Dewu Zhong; Zhonghua Tang; Meirong Zhou; Yu Zhu
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 273 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0167-6806
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## Abstract The xeroderma pigmentosum complementation group C (XPC) is responsible for removal of bulky helixβdistorting DNA lesions. Several polymorphisms of __XPC__ gene may modulate the colorectal cancer (CRC) susceptibility. We assessed the association of __XPC__ Lys939Gln (A/C), Ala499Val (C/T
## Abstract ## BACKGROUND Breast cancer (BC) is a complex disease, and the incidence rates for BC increase with age. Both environmental factors and genetics have an impact on the risk of BC. Although the effects of environmental factors may vary with age, it has been assumed generally that the pen