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Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome

✍ Scribed by Ashok Patel; Simon D. Rees; M. Ann Kelly; Steven C. Bain; Anthony H. Barnett; Deepak Thalitaya; Vee P. Prasher


Book ID
116772699
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
140 KB
Volume
487
Category
Article
ISSN
0304-3940

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## Abstract ## Objective Virtually all adults with Down syndrome (DS) have neuropathological manifestations of Dementia in Alzheimer's disease (DAD) but not all develop clinical psychopathology. The effect of allelic variants of Apolipoprotein (APOE) gene in development and progression of DAD and