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Variants in the CYP17 Cytochrome P450 gene are associated with dementia onset and risk of Alzheimer's disease in women with Down syndrome

✍ Scribed by Joseph H. Lee; Constance Chace; Rong Cheng; Deborah Pang; Catherine Cheng; Kyung T. Oh; Wayne Silverman; Warren Zigman; Benjamin Tycko; Nicole Schupf

Book ID: 118466418
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 131 KB
Volume: 6
Category: Article
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2010.05.642

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## Abstract ## Objective Virtually all adults with Down syndrome (DS) have neuropathological manifestations of Dementia in Alzheimer's disease (DAD) but not all develop clinical psychopathology. The effect of allelic variants of Apolipoprotein (APOE) gene in development and progression of DAD and