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Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip

✍ Scribed by Ingrid Meulenbelt; Albert B. Seymour; Marja Nieuwland; Tom W. J. Huizinga; Cornelia M. van Duijn; P. Eline Slagboom

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
88 KB
Volume
50
Category
Article
ISSN
0004-3591

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✦ Synopsis

Objective:

To study the role of the interleukin-1 beta gene (il1b) and the il-1 receptor antagonist gene (il1rn) in relation to the occurrence of radiographic osteoarthritis (roa) in the hip, knee, and hand and disc degeneration of the spine.

Methods:

The study population consisted of a random sample of 886 subjects (ages 55-65 years) from a population-based cohort (the rotterdam study). two polymorphisms within il1b (3953c>t and -511c>t) and one within il1rn (the variable-number tandem repeat [vntr]) were analyzed and used in an association study of the occurrence of roa. haplotyping and simultaneous logistic regression analysis were performed to investigate whether the associations observed were independent.

Results:

Associations with a predisposition for hip roa were observed for heterozygous and homozygous carriers of the rare il1b allele -511t (crude odds ratio [or] 1.8, 95% confidence interval [95% ci] 1.0-3.4 and or 2.9, 95% ci 1.4-6.3, respectively) and of the il1rn vntr allele 2 (crude or 2.0, 95% ci 1.1-3.4 and or 3.3, 95% ci 1.4-7.8, respectively). an additive effect was observed for carriers of risk alleles of both polymorphisms, with a significant linear-by-linear association (p = 0.00022).

Conclusion:

Our findings suggest that the il-1 gene cluster polymorphisms may play a significant role in the pathogenesis of oa of the hip.

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