Association of genotypes affecting the expression of interleukin-1β or interleukin-1 receptor antagonist with osteoarthritis
✍ Scribed by Verena Moos; Martin Rudwaleit; Volker Herzog; Kai Höhlig; Joachim Sieper; Brigitte Müller
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 83 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0004-3591
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Kainic acid, an analogue of glutamate, injected systemically to rats evokes seizures that are accompanied by nerve cell damage primarily in the limbic system. In the present study, we have analyzed the temporal profile of the expression of the cytokines interleukin-1 (IL-1) and IL-1 receptor antag
## Objective: To study the role of the interleukin-1 beta gene (il1b) and the il-1 receptor antagonist gene (il1rn) in relation to the occurrence of radiographic osteoarthritis (roa) in the hip, knee, and hand and disc degeneration of the spine. ## Methods: The study population consisted of a ran
## Abstract ## Objective To investigate whether the interleukin‐1 (IL‐1) ligand gene cluster at 2q13 encodes for genetic susceptibility to primary osteoarthritis (OA). ## Methods Seven single‐nucleotide polymorphisms (SNPs) and a variable‐number tandem repeat (VNTR) polymorphism from within the