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Association of the germlineTP53R337H mutation with breast cancer in southern Brazil

✍ Scribed by Juliana G Assumpção; Ana Luíza Seidinger; Maria José Mastellaro; Raul C Ribeiro; Gerard P Zambetti; Ramapriya Ganti; Kumar Srivastava; Sheila Shurtleff; Deqing Pei; Luiz Carlos Zeferino; Rozany M Dufloth; Silvia Regina Brandalise; José Andres Yunes


Book ID
115011422
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
227 KB
Volume
8
Category
Article
ISSN
1471-2407

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Detailed haplotype analysis at the TP53
✍ Sonia Garritano; Federica Gemignani; Edenir Inez Palmero; Magali Olivier; Ghysla 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 345 KB

Due to patterns of migration, selection, and population expansion, founder effects are common among humans. In Southern Brazil, a recurrent TP53 mutation, p.R337H, is detected in families with cancer predisposition. We have used whole locus resequencing and high-density single nucleotide polymorphis