𝔖 Bobbio Scriptorium
✦   LIBER   ✦

High frequency of the cancer-predisposing TP53 mutation R337H in the population of south Brazil – evidence for a founder effect

✍ Scribed by S. Garritano; S. Landi; F. Gemignani; O. Magali; G. Martel-Planche; R. Brentani; P. Ashton-Prolla; S. Tavtigian; P. Hainaut; M.I. Waddington Achatz


Book ID
119598563
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
89 KB
Volume
6
Category
Article
ISSN
1359-6349

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Detailed haplotype analysis at the TP53
✍ Sonia Garritano; Federica Gemignani; Edenir Inez Palmero; Magali Olivier; Ghysla 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 345 KB

Due to patterns of migration, selection, and population expansion, founder effects are common among humans. In Southern Brazil, a recurrent TP53 mutation, p.R337H, is detected in families with cancer predisposition. We have used whole locus resequencing and high-density single nucleotide polymorphis