Association of the −31C/T functional polymorphism in the interleukin-1β gene with the intractability of Graves' disease and the proportion of T helper type 17 cells
✍ Scribed by F. Hayashi; M. Watanabe; T. Nanba; N. Inoue; T. Akamizu; Y. Iwatani
- Book ID
- 108701121
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 177 KB
- Volume
- 158
- Category
- Article
- ISSN
- 0009-9104
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The recent discovery and characterization of T helper 17 cells (Th17) and their signature cytokines (IL-17) represents a hallmark in T-cell immunobiology by providing a new distinctive pathway for the communication between adaptive and innate immunity. From the six members of the IL-17 cytokine fami
## 817 ated with increased risk for AD, at least in the Korean population. Nevertheless, it cannot be excluded that the association between IL-1A (-889) C/T polymorphism and AD observed in previous studies might be the result of linkage disequilibrium with a yet unidentified gene on chromosome 2.