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Association of NOD2 with Crohn's Disease in a homogenous Irish population

✍ Scribed by Bairead, Emer; Harmon, Dawn L; Curtis, Anne M; Kelly, Yvette; O'Leary, Clare; Gardner, Michelle; Leahy, Dermot T; Vaughan, Pat; Keegan, Denise; O'Morain, Colm


Book ID
110025371
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
116 KB
Volume
11
Category
Article
ISSN
1018-4813

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Background: NOD2 is an intracellular protein involved in host recognition of specific bacterial molecules and is genetically associated with several inflammatory diseases, including Crohn's disease (CD). NOD2 stimulation activates the transcription factor, NF-B, through RIP2, a caspase-recruitment d