Association of leukotriene B4 with the cytoskeleton of rabbit neutrophils, effect of chemotactic factor and phorbol esters
β Scribed by Paul H. Naccache; Thaddeus F.P. Molski; Pierre Borgeat; Rasadan I. Sha'afi
- Book ID
- 115757751
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 352 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
Human neutrophils biosynthesize the chemoattractant leukotriene B4 (LTB4) and metabolize LTB4 to omega oxidative products 20-hydroxy-LTB4 (20-OH-LTB4) and 20-carboxy-LTB4 (20-COOH-LTB4). In this study, we prepared the C-1 methyl ester and N-methyl amide of LTB4 and then examined neutrophil chemotaxi
## Abstract The preincubation of rabbit neutrophils with the chemotactic factor FβMetβLeuβPhe and the subsequent addition of cytochalasin B has previously been shown to induce a time, concentration and calcium dependent loss of secretory responsiveness in neutrophils. This has been termed desensiti