Deactivation of the effects of f-Met-Leu-Phe and leukotriene B4 on calcium mobilization in rabbit neutrophils
โ Scribed by R.I. Sha'afi; T.F.P. Molski; P. Borgeat; P.H. Naccache
- Book ID
- 118315333
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 420 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0006-291X
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The possible involvement of membrane-bound calcium in the mechanism of action of leukotriene B4 was examined using the fluorescent chelate probe, chlortetracycline. Leukotriene B4 was found to cause a rapid release of membrane-bound calcium at physiologically relevant concentrations. This effect of
We have found that exogenous leukotriene B, modifies calcium homeostasis in rabbit neutrophils in a manner essentially analogous to that of the chemotactic peptide f-Met-Leu-Phe. Leukotriene B, causes a rapid and dosedependent increase in membrane permeability to calcium and a release of calcium fro