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Association of Insulin Receptor Substrate 3 with SH2 Domain-Containing Proteins in Rat Adipocytes

✍ Scribed by Stuart A. Ross; Gustav E. Lienhard; Brian E. Lavan


Book ID
115582256
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
224 KB
Volume
247
Category
Article
ISSN
0006-291X

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The 68 kDa Src substrate associated during mitosis (Sam68) is an RNA binding protein with Src homology (SH) 2 and 3 domain binding sites. We have recently found that Sam68 is a substrate of the insulin receptor (IR) that translocates from the nucleus to the cytoplasm and that Tyr-phosphorylated Sam6