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p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K

✍ Scribed by Víctor Sánchez-Margalet; Souad Najib

Book ID
117111159
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
184 KB
Volume
455
Category
Article
ISSN
0014-5793

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Sam68 associates with the SH3 domains of
Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling
✍ Souad Najib; Víctor Sánchez-Margalet 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 176 KB

The 68 kDa Src substrate associated during mitosis (Sam68) is an RNA binding protein with Src homology (SH) 2 and 3 domain binding sites. We have recently found that Sam68 is a substrate of the insulin receptor (IR) that translocates from the nucleus to the cytoplasm and that Tyr-phosphorylated Sam6