Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency
✍ Scribed by Nima Rezaei; Asghar Aghamohammadi; Mahdi Mahmoudi; Yadollah Shakiba; Gholam Ali Kardar; Maryam Mahmoudi; Batoul Moradi; Ali Akbar Amirzargar
- Book ID
- 116569400
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 152 KB
- Volume
- 215
- Category
- Article
- ISSN
- 0171-2985
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## Abstract The purpose of this study was to evaluate whether IL‐1 β (IL‐1β promoter and IL‐1β exon 5), IL‐1 receptor antagonist (IL‐1 __Ra__), and IL‐4 (IL‐4 promoter and IL‐4 intron 3) gene polymorphisms act as markers of susceptibility to Kawasaki disease (KD), or of the severity of the disease.
## Abstract Interleukin‐4 (IL‐4) is a cytokine with anti‐inflammatory properties. Tumor necrosis factor alpha (TNF‐α), a pluripotent proinflammatory cytokine, plays an important role in the process of numerous inflammatory and autoimmune diseases. We aimed to investigate whether gene polymorphisms