Association of EXT1 and EXT2, Hereditary Multiple Exostoses Gene Products, in Golgi Apparatus
โ Scribed by Shin-ichiro Kobayashi; Ko-ichi Morimoto; Takahiko Shimizu; Mayumi Takahashi; Hisashi Kurosawa; Takuji Shirasawa
- Book ID
- 115585310
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 409 KB
- Volume
- 268
- Category
- Article
- ISSN
- 0006-291X
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Hereditary multiple exostoses (EXT) is an autosomal dominant disorder characterized by the formation of exostoses, which are cartilage-capped bony protuberances mainly located on long bones. Two genes, EXT1 and EXT2, and at least one other unidentified gene, are known to be involved in the formation
Hereditary multiple exostoses (EXT) is an autosomal dominant disorder characterized by growth of benign bone tumors. Three chromosomal loci have been implicated in this genetically heterogeneous disease: EXT1 at 8q24, EXT2 at 11p13, and EXT3 on 19p. EXT1 and EXT2 were recently cloned. We evaluated 3