Association of endogenous anti–interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus
✍ Scribed by Alyssa M. Morimoto; Donna Thibault Flesher; Jihong Yang; Kristen Wolslegel; Xiangdan Wang; Ann Brady; Alexander R. Abbas; Valerie Quarmby; Eric Wakshull; Bruce Richardson; Michael J. Townsend; Timothy W. Behrens
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 520 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective Gene‐expression studies have demonstrated increased expression of interferon (IFN)–inducible genes (IFIGs) in peripheral blood mononuclear cells (PBMCs) of many patients with systemic lupus erythematosus (SLE), with a predominant effect of type I IFN. This study examined t
## Abstract ## Objective Interferon‐α (IFNα) is a primary pathogenic factor in systemic lupus erythematosus (SLE), and high IFNα levels may be associated with particular clinical manifestations. The prevalence of individual clinical and serologic features differs significantly by ancestry. This st