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Association of CYP2D6∗3 and CYP2D6∗10 genetic polymorphism on the Donepezil metabolism with Alzheimer's patients

✍ Scribed by Subbiah Vivekanandhan; Nirmal Sonali; Munisamy Murali; Tripathi Manjari; Sagar Rajesh

Book ID
118466407
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
43 KB
Volume
6
Category
Article
ISSN
1552-5260

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## Abstract ## Objective Risperidone is converted to 9‐hydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of co‐medication on risperidone metabolism: the risperidone:9‐hydroxyrisperidone concentration ratio (R:9‐OHR ratio) and the sum of the