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Association of common missense changes inELAC2(HPC2) with prostate cancer in a Japanese case–control series

✍ Scribed by H. Fujiwara; M. Emi; H. Nagai; T. Nishimura; N. Konishi; Y. Kubota; T. Ichikawa; S. Takahashi; T. Shuin; T. Habuchi; O. Ogawa; K. Inoue; M. H. Skolnick; J. Swensen; N. J. Camp; S. V. Tavtigian


Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
220 KB
Volume
47
Category
Article
ISSN
1435-232X

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## Abstract The __HPC2__/__ELAC2__ gene may be associated with hereditary/familial prostate cancer (PCa). Two common missense variants (Ser217Leu and Ala541Thr) have been reported in the gene. We performed mutational, allelotyping and expression analyses and a molecular epidemiological study to cla