Association of anti-paternal antibodies and recurrent spontaneous abortion
β Scribed by Shlomit Orgad; Howard J. Carp; Ephriam Gazit; J. Bruce Smith; F. S. Cowchock
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 193 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0004-3591
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The incidence of pregnancy loss is higher in patients with various autoimmune diseases than in the general population. The causes of recurrent spontaneous abortions (RSA) are unknown; however, the presence of antinuclear antibodies and other antibodies in some women with RSA who are otherwise health
## Abstract We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzymeβlinked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and Ξ²~2~βglycoprotein I (Ξ²~2~βGPI). Sixteen patients (7.5%) were positiv
Antibodies to negatively charged phospholipids are associated with a predisposition to both arterial and venous thrombosis, recurrent fetal wastage, and thrombocytopenia. These associations have been reported in patients who do not fulfill criteria for connective tissue diseases. In this study, we d