β2-GPI-dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions

✍ Scribed by Dr. Nobuaki Ozawa; Tsunehisa Makino; Hidehiko Matsubayashi; Tomotoshi Hosokawa; Ken-Ichi Someya; Shiro Nozawa; Eiji Matsuura

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 378 KB
• Volume: 8
• Category: Article
• ISSN: 0887-8013
• DOI: 10.1002/jcla.1860080502

✦ Synopsis

Abstract

We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme‐linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β~2~‐glycoprotein I (β~2~‐GPI). Sixteen patients (7.5%) were positive for β~2~‐GPI‐dependent aCL. Though β~2~‐GPI appeared to enhance the binding of aCL, β~2~‐GPI‐independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β~2~‐GPI‐dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. © 1994 Wiley‐Liss, Inc.