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Association of −318 C/T and +49 A/G cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms with a clinical subset of Italian patients with systemic sclerosis

✍ Scribed by G. Balbi; F. Ferrera; M. Rizzi; P. Piccioli; A. Morabito; L. Cardamone; M. Ghio; G. L. Palmisano; P. Carrara; S. Pedemonte; M. Sessarego; M. De Angioletti; R. Notaro; F. Indiveri; M. P. Pistillo


Book ID
108699619
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
164 KB
Volume
149
Category
Article
ISSN
0009-9104

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✍ KEMP; AJJAN; WATERMAN; GAWKRODGER; CORK; WATSON; WEETMAN 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 285 KB

The CTLA-4 gene encodes a T-cell receptor that is involved in the regulation of T-cell activation. Recent studies have demonstrated an association of a microsatellite polymorphism [variant lengths of a dinucleotide (AT)n repeat] lying in exon 3 of the CTLA-4 gene, specifically a 106-bp allele, with