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Association between α1-antichymotrypsin signal peptide −15A/T polymorphism and the risk of Alzheimer’s disease: a meta-analysis

✍ Scribed by Fulin Guan; Jiaao Gu; Fulan Hu; Yulan Zhu; Weizhi Wang

Book ID: 113075950
Publisher: Springer
Year: 2012
Tongue: English
Weight: 481 KB
Volume: 39
Category: Article
ISSN: 0301-4851
DOI: 10.1007/s11033-012-1472-8

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A common polymorphism in the α1-antichymotrypsin (ACT) gene has been found to modify the APOE\*4-associated risk of Alzheimer's disease due to an apparent interaction between the two loci. This study was undertaken to determine the gender-and age-related distributions of these two polymorphisms in t