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Association between the functional polymorphism in the matrix metalloproteinase-7 promoter and susceptibility to adult astrocytoma

✍ Scribed by Zhongqiang Lu; Yimin Wang; Qingjun Zhang; Xianghong Zhang; Shuheng Wang; Huiling Xie; Yuehong Li; Baohua Jiao; Jianhui Zhang

Book ID: 113502134
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 264 KB
Volume: 1118
Category: Article
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2006.08.007

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## Abstract Matrix metalloproteinases (MMPs) play an important role in several steps of cancer development. A single guanine insertion polymorphism (2G) in the __MMP1__ promoter sequence at −1,607 creates an Ets binding site and thus results in enhancing transcriptional activity. This study aimed t