As people with Down syndrome (DS) age, they are at greater risk for Alzheimer disease (AD) than the general population. It has been suggested that polymorphisms at the genes for presenilin-1 (PS-1) and β£-1antichymotrypsin (ACT) confer an increased risk for AD in the general population, and therefore
Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome
β Scribed by Petersen, Michael B. ;Karadima, Georgia ;Samaritaki, Maria ;Avramopoulos, Dimitris ;Vassilopoulos, Dimitris ;Mikkelsen, Margareta
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 101 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0148-7299
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## Wragg et al. [1996: Lancet 347:509-512] recorded an association between the intronbased presenilin 1 (PS1) genotype 1/1 and late-onset Alzheimer's disease (AD). This study was performed to determine if there is a similar association in the Chinese population. Ninety-one AD cases, 50 multiinfarc
Mutations in the Presenilin 1 (PS1) gene on chromosome 14 cause most early-onset familial Alzheimer's disease (AD). An intronic polymorphism in the PS1 gene was recently identified and reported to be associated with late-onset AD [Wragg et al., Lancet 347: 509-512, 1996]. The authors found an excess