Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women
✍ Scribed by Ingeborg Zehbe; Joannis Mytilineos; Ingrid Wikström; Rudi Henriksen; Lutz Edler; Massimo Tommasino
- Book ID
- 117415188
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 82 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0198-8859
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The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within
Infection with high-risk human papillomavirus (HPV) is necessary for the development of a cervical lesion, but only a fraction of precursor lesions progress to cancer. Additional factors, other than HPV type per se, are likely to increase the probability for progression. Intratype genome variations