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Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women

✍ Scribed by Ingeborg Zehbe; Joannis Mytilineos; Ingrid Wikström; Rudi Henriksen; Lutz Edler; Massimo Tommasino


Book ID
117415188
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
82 KB
Volume
64
Category
Article
ISSN
0198-8859

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Human papillomavirus type 16 E6 variants
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The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within

Human papillomavirus 16 E6 polymorphisms
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Infection with high-risk human papillomavirus (HPV) is necessary for the development of a cervical lesion, but only a fraction of precursor lesions progress to cancer. Additional factors, other than HPV type per se, are likely to increase the probability for progression. Intratype genome variations