✦ LIBER ✦

Association between depression and survival or disease recurrence in patients with head and neck cancer enrolled in a depression prevention trial

✍ Scribed by Kathryn E. Lazure; William M. Lydiatt; David Denman; William J. Burke

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 129 KB
Volume: 31
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21046

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

To determine if depression portends a worse prognosis in patients with head and neck cancer, we conducted a retrospective chart analysis of subjects who participated in a randomized placebo‐controlled trial of citalopram for the prevention of depression during head and neck cancer treatment. Thirty‐five patients were randomized, 34 with 1 or more evaluations form the basis of this report.

Methods.

We used the Hamilton Depression Rating Scale (HDRS), with a minimum follow‐up of 24 months if no evidence of disease, or until recurrence or death from disease.

Results.

Fourteen of 34 subjects were depressed at any time during the 16 week RCT (HAMD >15). Seven of the 14 subjects in the depressed group were dead from disease or had recurrence, compared to 4 of 20 who never developed depression (p = .03). Stage of disease was equivalent in the 2 groups.

Conclusion.

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