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Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population

✍ Scribed by Jinyun Chen; Subrata Sen; Christopher I. Amos; Chongjuan Wei; J. Shawn Jones; Patrick Lynch; Marsha L. Frazier

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
129 KB
Volume
46
Category
Article
ISSN
0899-1987

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✦ Synopsis

Abstract

Aurora‐A kinase is considered a potential cancer susceptibility gene that encodes a centrosome‐associated, cell cycle‐regulated serine/threonine kinase. We studied two single nucleotide polymorphisms (SNP) in the coding region of Aurora‐A, 91T‐to‐A (F31I) and 169G‐to‐A (V57I). We studied the influence of these two polymorphisms on age of onset of hereditary nonpolyposis colorectal cancer (HNPCC). Genotyping of the Aurora‐A polymorphisms was carried out on 125 Caucasian with mismatch repair (MMR) gene mutations with real‐time pyrophosphate DNA sequencing. For the 91T‐to‐A polymorphism, we found that patients with HNPCC who were homozygous for the wild‐type allele developed colorectal cancer (CRC) 7 years earlier than patients who were homozygous or heterozygous for the mutant allele. The169G‐to‐A polymorphism did not have a significant influence on risk for HNPCC. However, when we did haplotype analysis for these two polymorphisms, the 91A‐169G haplotype was associated with protection from HNPCC at an earlier age. © 2006 Wiley‐Liss, Inc.

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