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Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk

✍ Scribed by Jiangong Niu; Yu-Jing Huang; Sheng Wei; Zhensheng Liu; Li-E Wang; Shine Chang; Robert M. Chamberlain; Adel K. El-Naggar; Erich M. Sturgis; Qingyi Wei

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
280 KB
Volume
33
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

To the best of our knowledge, no studies to date have evaluated roles of insulin‐like growth factor binding protein 5 (IGFBP5) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN).

Methods.

A hospital‐based study of 1082 patients with SCCHN and 1120 cancer‐free controls was performed to investigate associations between 2 functional polymorphisms, ‐1195T>C and ‐709G>C, in the IGFBP5 promoter region and SCCHN risk.

Results.

We demonstrated that the transcription factor, activator protein 1 (AP‐1), differentially bound to T or C variants at ‐1195 in the promoter to regulate the IGFBP5 promoter activity and that the C variant genotypes were associated with deferential risk of late‐stage SCCHN, compared to the TT genotype, particularly for human papillomavirus (HPV)‐unrelated sites (adjusted odds ratio [OR], 2.21; 95% confidence interval [CI], 1.19–4.11 for CC vs TT).

Conclusion.

The IGFBP5 ‐1195T>C polymorphism is functional and may potentially be a biomarker for susceptibility to late‐stage SCCHN. © 2010 Wiley Periodicals, Inc. Head Neck, 2011

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