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Association analysis of the −308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia

✍ Scribed by R. Hashimoto; M. Yoshida; N. Ozaki; Y. Yamanouchi; N. Iwata; T. Suzuki; T. Kitajima; M. Tatsumi; K. Kamijima; H. Kunugi

Publisher
Springer
Year
2004
Tongue
English
Weight
131 KB
Volume
111
Category
Article
ISSN
1435-1463

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The striking evidence of almost 100% association of narcolepsy with human leukocyte antigens (HLA) DR2(DR15) antigen is an important clue to elucidate the molecular basis of this sleep disorder. The gene for tumor necrosis factor ␣ (TNF ␣) is located in the HLA class II gene cluster. Recent studies