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Assignments of 1H and 13C NMR spectral data for ondansetron and its two novel metabolites, 1-hydroxy-ondansetron diastereoisomers

✍ Scribed by Mingyu Duan; Haihua Huang; Xinnan Li; Xiaoyan Chen; Dafang Zhong


Book ID
102525697
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
150 KB
Volume
44
Category
Article
ISSN
0749-1581

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✦ Synopsis


Abstract

Assignments of ^1^H and ^13^C NMR chemical shifts were made by means of heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bond correlation (HMBC) experiments for ondansetron, and by means of ^1^H‐^1^H correlation spectroscopy (^1^H‐^1^H COSY) and two‐dimensional nuclear Overhauser effect spectroscopy (NOESY) experiments for two novel metabolites (M1 and M2) of ondansetron. These two metabolites were isolated for the first time from Mucor circinelloides. Copyright © 2006 John Wiley & Sons, Ltd.


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