Assignment of the rat genes coding for DOPA decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2)

✍ Scribed by Cécile Vassort; Michèle Rivière; Gilles Bruneau; François Gros; Jean Thibault; Göran Levan; Josiane Szpirer; Claude Szpirer

• Book ID: 104766862
• Publisher: Springer-Verlag
• Year: 1993
• Tongue: English
• Weight: 771 KB
• Volume: 4
• Category: Article
• ISSN: 0938-8990
• DOI: 10.1007/bf00417563

✦ Synopsis

By use of rat cDNA probes and a panel of cell hybrids segregating rat chromosomes, the genes encoding three pyridoxal 5'-phosphate (PLP)-dependent decarboxylases--namely, DOPA-decarboxylase (Ddc), glutamic acid decarboxylase 1 and 2 (Gad1 and Gad2)--were assigned to rat Chromosomes (Chrs) 14, 3, and 17, respectively. If one takes into account chromosome localizations in the human and the mouse, the present results (i) show that a synteny group is retained on rat Chr 14, human Chr 7, and mouse Chr 11 (Ddc); (ii) strengthen the homology relation known between rat Chr 3 and human and mouse Chrs 2 (Gad1); (iii) suggest that rat Chr 17 has no extensive homology to any human chromosome; and (iv) suggest the order (Prl, Fdp)--Tpl2--Gad2 on the rat Chr 17.