Assignment of the bovine p53 gene (TP53) to Chromosome 19q15 by fluorescence in situ hybridization

✍ Scribed by L. W. Coggins; L. Scobie; M. E. Jackson; M. S. Campo

• Publisher: Springer-Verlag
• Year: 1995
• Tongue: English
• Weight: 313 KB
• Volume: 6
• Category: Article
• ISSN: 0938-8990
• DOI: 10.1007/bf00352389

✦ Synopsis

Brief Data Reports 687 suggests human Chr 1 p is syntenic to at least three bovine chromosomes: 16(U1), 2(U17), and 3(U6) [1,10,11]. In this comparative map, bovine synteny group U6 is apparently homologous to the p13-21 region of human Chr 1. Since a previous analysis utilizing microsatellite markers extended the U6 (Chr 3) linkage group to 92.3 cM [1], the assignment of G-CSFR at the end of the bovine U6 (Fig. 2) suggests that U6 encompasses not only the regions corresponding to human Chr 1 p13-21, but also the p35 region where human G-CSFR has been assigned. In summary, our data demonstrate that G-CSFR maps to bovine Chr 3 (synteny group U6), and this assignment extends synteny conservation between human Chr 1 and bovine Chr 3.

Acknowledgments: We thank Dr. Shigekazu Nagata (Osaka Bioscience Institute, Japan) for providing us the human G-CSFR cDNA probe.