Sheep x hamster cell hybrids containing sheep metacentric Chromosome (Chr) 2 were produced by fusing blood leukocytes from normal sheep with hamster auxotrophic Ade F-minus mutants. Cell clones that were isocitrate dehydrogenase 1 (IDH1) positive were cytogenetically characterized, confirming that t
Assignment of 22 loci in the rat by somatic hybrid and linkage analysis
โ Scribed by Raymond S. Yeung; Okio Hino; Maria Vilensky; Kenneth Buetow; Claude Szpirer; Josiane Szpirer
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 469 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0938-8990
No coin nor oath required. For personal study only.
โฆ Synopsis
Twenty structural genes and two unique anonymous DNA fragments have been mapped in the rat (Rattus norvegicus) with a panel of mouse x rat hybrids and linkage analysis. Ten of the 20 autosomes are represented by at least one of these markers. A new syntenic relationship among rat Chromosome (Chr) 16, mouse Chr 14, and human Chr 10q was established. Results of this study further support the extensive conservation of synteny between the rat and mouse and, to a lesser degree, between rat and human.
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Progeny produced from Bombina bombina, B. variegata, and field-collected interspecific hybrids have been analyzed for the inheritance of five enzyme loci, which are fixed for alternate alleles in the parental species. Lactate dehydrogenase (Ldh-1), NAD-dependent malate dehydrogenase (Mdh-1), creatin